English

Doctoral course in the Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences

  • Professor: TAKAMURA, Toshinari, MD & PhD
  • Associate Professor: MISU, Hirofumi, MD & PhD

The nature ascertains a pivotal role for every biological system like clockwork and is unlikely to maintain systems that are detrimental for survival. Any pathway and molecule that causes illness must also have a meaningful role. Overnutrition disrupts inter-organ networks to keep energy homeostasis governed by the liver. Our group has identified key pathways and molecules (hepatokine world) through comprehensive gene expression analyses of tissue and cell samples from humans and model animals. Through functional analyses of these diagnostic/therapeutic targets, we aim to create medical systems for preclinical diagnosis and preemptive/tailor-made medicine.

Research projects

  1. Molecular pathology and clinical research in diabetes/obesity and its complications
  2. Cross-talks among glucose-, protein-, and lipid-metabolism pathways to keep energy homeostasis
  3. Hepatokine-receptor-mediated inter-organ


Figure
Pathology of type 2 diabetes caused by a liver-derived hormone hepatokine

The liver plays a role as an endocrine organ to produce functional hepatokines and thereby mediates fatty liver-associated systemic pathology. We discovered a liver-derived hormone selenoprotein P that causes multi-signal resistances via reductive stress leading to pathology of type 2 diabetes such as insulin resistance, angiogenesis resistance, exercise resistance, and insulin secretory failure.